VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.

Itu Singh Mallika LavaniaVinay Kumar PathakMadhvi AhujaRavindra P TurankarVikram SinghUtpal Sengupta

Published in: PLoS neglected tropical diseases (2018)

Blood levels of vitamin D do not play any role in clinical manifestations of any forms of leprosy. ff genotype of Fok1 and tt genotype of Taq1 was found to be associated with leprosy per se. Association of t-F-a haplotype with leprosy was found to be significant and could be used as a genetic marker to identify individuals at high risk for developing leprosy. VDR gene expression was lower in TT/BT and BL/LL groups of leprosy in comparison to that of healthy controls.

Keyphrases

gene expression
dna methylation
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
patient reported outcomes
tertiary care
patient reported