Patient-Derived Xenografts Can Be Reliably Generated from Patient Clinical Biopsy Specimens.
Matthew C HernandezJohn R BergquistJennifer L LeitingTommy IvanicsLin YangRory L SmootDavid M NagorneyMark J TrutyPublished in: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (2019)
PDX models can be successfully created from clinical biopsy specimens in patients with metastatic or unresectable GI cancers. The use of clinical biopsy specimens for PDX engraftment can expand the repertoire of stage-specific PDX models for downstream basic/translational research.