Pregabalin poisoning: Evaluation of dose-toxicity relationship.
Saskia J RietjensMaaike A SikmaClaudine C HunaultDylan W de LangeLaura HondebrinkPublished in: British journal of clinical pharmacology (2021)
In general, higher pregabalin doses result in more severe poisonings. Below 20 mg kg-1 the majority of patients (83%) only suffer from mild poisoning. However, large interindividual differences exist in pregabalin-induced toxicity. Therefore, pre-hospital triage should not only include pregabalin dose, but also underlying illnesses, co-exposures and reported symptoms.
Keyphrases
- patient reported outcomes
- neuropathic pain
- postoperative pain
- emergency department
- oxidative stress
- spinal cord injury
- healthcare
- spinal cord
- end stage renal disease
- air pollution
- early onset
- chronic kidney disease
- ejection fraction
- drug induced
- newly diagnosed
- diabetic rats
- physical activity
- depressive symptoms
- peritoneal dialysis
- adverse drug
- acute care
- patient reported