Clinical Validation of Human Papilloma Virus Circulating Tumor DNA for Early Detection of Residual Disease After Chemoradiation in Cervical Cancer.
Kathy HanJinfeng ZouZhen ZhaoZeynep BaskurtYangqiao ZhengElizabeth BarnesJennifer CrokeSarah E FergusonAnthony FylesLilian T GienAdam GladwishMagali Lecavalier-BarsoumStéphanie LheureuxJelena LukovicHelen MackayEve-Lyne MarchandUr MetserMichael MilosevicAmandeep S TaggarScott V BratmanEric LeungPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Persistent HPV ctDNA after CRT is independently associated with inferior PFS. HPV ctDNA testing can identify, as early as at the end of CRT, patients at high risk of recurrence for future treatment intensification trials.