Conferring extracellular matrix affinity enhances local therapeutic efficacy of anti-TNF-α antibody in a murine model of rheumatoid arthritis.

Kiyomitsu KatsumataJun IshiharaKazuto FukunagaAko IshiharaEiji YubaErica BudinaJeffrey A Hubbell

Published in: Arthritis research & therapy (2019)

These data demonstrate that retention of α-TNF in arthritic joints can suppress arthritis development and enhance therapeutic efficacy. This simple bioengineering approach of ECM-binding peptide conjugation offers a powerful and clinically translational approach to treat RA.

Keyphrases

rheumatoid arthritis
extracellular matrix
disease activity
interstitial lung disease
ankylosing spondylitis
electronic health record
big data
binding protein
systemic lupus erythematosus
dna binding
transcription factor
capillary electrophoresis