Dose-response relationship of MSCs as living Bio-drugs in HFrEF patients: a systematic review and meta-analysis of RCTs.

Ziyad T Ahmed Maha Saad Zain Al-Abeden Mohamed Ghaith Al Abdin Mohamad Ayham Muqresh Ghazi I Al Jowf Lars M T Eijssen Khawaja Husnain Haider

Published in: Stem cell research & therapy (2024)

Low-dose MSC treatment was safe and superior to high-dose treatment in restoring efficacy and functional outcomes in heart failure patients, and further analysis in a larger patient group is warranted.

Keyphrases

low dose
high dose
ejection fraction
end stage renal disease
chronic kidney disease
mesenchymal stem cells
prognostic factors
combination therapy
case report
bone marrow
drug induced