Defining rules governing recognition and Fc-mediated effector functions to the HIV-1 co-receptor binding site.

William D TolbertRebekah SherburnNeelakshi GohainShilei DingRobin FlinkoChiara OrlandiKrishanu RayAndrés FinziGeorge K LewisMarzena E Pazgier

Published in: BMC biology (2020)

Our data identify a previously unknown binding site for TYS within the assembled CoRBS of the HIV-1 virus. In addition, our combined structural-modeling-functional analyses provide new insights into mechanisms of Fc-effector function of antibodies against HIV-1, in particular, how antibody binding to Env antigen affects the efficiency of ADCC response.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
men who have sex with men
regulatory t cells
south africa
type iii
electronic health record
deep learning