Assessment of Proximal Tubular Function by Tubular Maximum Phosphate Reabsorption Capacity in Heart Failure.
Johanna Elisabeth EmmensMartin H de BorstEva M BoorsmaKevin DammanGerjan NavisDirk J van VeldhuisenKenneth DicksteinStefan D AnkerChim C LangGerasimos FilippatosMarco MetraNilesh J SamaniPiotr PonikowskiLeong L NgAdriaan A VoorsJozine M Ter MaatenPublished in: Clinical journal of the American Society of Nephrology : CJASN (2022)
TmP/GFR, a measure of proximal tubular function, is frequently reduced in heart failure, especially in patients with more advanced heart failure. Lower TmP/GFR is furthermore associated with future risk of plasma NGAL doubling and worse clinical outcomes, independent of glomerular function.