High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19.
Anders Aune TveitaSarah Louise MurphyJan Cato HolterAnders Benjamin KildalAnnika E MichelsenTøri Vigeland LerumMari KaarbøLars HeggelundAleksander Rygh HoltenAne Kristine FinbråtenKarl Erik MüllerAlexander MathiessenSimen BøeBørre FevangBeathe Kiland GranerudKristian TonbyAndreas LindSusanne Gjeruldsen DudmanKaterina Nezvalova HenriksenFredrik MüllerOle Henning SkjønsbergMarius TrøseidAndreas Barratt-DueAnne Ma Dyrhol-RiisePål AukrustBente HalvorsenTuva Børresdatter DahlThor Uelandnull nullnull nullPublished in: The Journal of infectious diseases (2022)
Our findings highlight CCL19 and CCL21 as markers of immune dysregulation in Covid-19. This may reflect aberrant regulation triggered by tissue inflammation, as observed in other chronic inflammatory and autoimmune conditions. Determination of the source and regulation of these chemokines and their effects on lung tissue is warranted to further clarify their role in Covid-19.