Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes.

Rebecca K West Abigail Livny Ramit Ravona-Springer Barbara B Bendlin Anthony D Heymann Derek Leroith Xiao-Yu Liu Hung-Mo Lin Hagit Hochner Yechiel Friedlander Ithamar Ganmore Amir Tirosh Michal Schnaider Beeri

Published in: Diabetologia (2020)

In older adults with type 2 diabetes, long-term adiposity may have a detrimental impact on volume of brain regions relevant to cognitive functioning. Further studies to identify the underlying mechanisms are warranted. Graphical abstract.

Keyphrases

cerebral ischemia
physical activity
weight gain

insulin resistance
type diabetes
adipose tissue

white matter
resting state
skeletal muscle

weight loss
functional connectivity