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Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes.

Rebecca K WestAbigail LivnyRamit Ravona-SpringerBarbara B BendlinAnthony D HeymannDerek LeroithXiao-Yu LiuHung-Mo LinHagit HochnerYechiel FriedlanderIthamar GanmoreAmir TiroshMichal Schnaider Beeri
Published in: Diabetologia (2020)
In older adults with type 2 diabetes, long-term adiposity may have a detrimental impact on volume of brain regions relevant to cognitive functioning. Further studies to identify the underlying mechanisms are warranted. Graphical abstract.
Keyphrases
  • cerebral ischemia
  • physical activity
  • weight gain
  • insulin resistance
  • type diabetes
  • adipose tissue
  • white matter
  • resting state
  • skeletal muscle
  • weight loss
  • functional connectivity