Attenuation of intrinsic ageing of the skin via elimination of senescent dermal fibroblasts with senolytic drugs.

H KimJ JangMin Ji SongG KimC-H ParkDong Hoon Lee Si-Hyung Lee Jin Ho Chung

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

Taken together, our results indicate that selective clearance of senescent skin cells can attenuate and improve skin ageing phenotypes and that senolytic drugs may be of potential use as new therapeutic agents for treating ageing of the skin.

Keyphrases

wound healing
soft tissue
induced apoptosis
oxidative stress
cell death
climate change
human health