Intracellular offspring released from SFB filaments are flagellated.

Iris NkambaCéline MuletGyanendra P DubeyOlivier GorgetteAurélie CouesnonAudrey SallesMaryse Moya-NilgesVincent JungValérie Gaboriau-RouthiauIda Chiara GuerreraTatsuichiro ShimaYoshinori UmesakiGiulia NigroJacomina Krijnse-LockerMarion BérardNadine Cerf-BensussanPhilippe J SansonettiPamela Schnupf

Published in: Nature microbiology (2019)

The gut commensal segmented filamentous bacterium (SFB) attaches to the ileal epithelium and potently stimulates the host immune system. Using transmission electron microscopy (TEM), we show that mouse and rat SFB are flagellated above the concave tip at the unicellular intracellular offspring (IO) stage and that flagellation occurs prior to full IO differentiation and release of IOs from SFB filaments. This finding adds a missing link to the SFB life cycle.

Keyphrases

life cycle
electron microscopy
high fat diet
reactive oxygen species
oxidative stress
adipose tissue
insulin resistance