Decreased Renal Gluconeogenesis Is a Hallmark of Chronic Kidney Disease.
Thomas VerissimoAnna FaivreAnna RinaldiMaja LindenmeyerVasiliki DelitsikouChristelle Veyrat-DurebexCarolyn HeckenmeyerMarylise FernandezLena BerchtoldDelal DalgaClemens CohenMaarten NaesensSven-Erik RickstenPierre-Yves MartinJérôme PuginFranck MerlierKarsten HauptJoseph M RutkowskiSolange MollPietro E CippàDavid LegouisSophie de SeigneuxPublished in: Journal of the American Society of Nephrology : JASN (2022)
Renal gluconeogenic function is impaired in CKD. Altered renal gluconeogenesis leads to systemic metabolic changes with a decrease in glucose and increase in lactate level, and is associated with a worse renal prognosis.