Mutational Analysis of 472 Urothelial Carcinoma Across Grades and Anatomic Sites.
Amin H NassarRenato UmetonJaegil KimKevin LundgrenLauren HarshmanEliezer M Van AllenMark PrestonFei DongJoaquim BellmuntKent W MouwToni K ChoueiriGuru SonpavdeDavid J KwiatkowskiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our analysis suggests that a fraction of MIBCs likely arise from precursor lesions other than LG-NMIBC. KDM6A mutations are twice as common in women with LG-NIMBC than those in men. DDR gene mutations and APOBEC mutagenesis drive mutations in HG-NMIBC and MIBC. UTUC has a distinct mutation profile from bladder cancer.