Molecularly imprinted and cladded polymers for constructing a portable plasmonic immunoassay for peptides in biofluids.
Zhanchen GuoQi ZhangRongrong XingZhen LiuPublished in: Chemical communications (Cambridge, England) (2023)
Using two molecularly imprinted and cladded polymers (cMIPs), an inexpensive, fast and portable plasmonic immuno-sandwich assay (PISA) was rationally developed for high-specificity and ultra-sensitive detection of C-peptide in urine. The dual cMIPs-based PISA allowed healthy individuals to be distinguished from diabetes patients and exhibited several significant merits over existing immunoassays, holding great promise in clinical diagnosis.
Keyphrases
- molecularly imprinted
- sensitive detection
- solid phase extraction
- end stage renal disease
- quantum dots
- newly diagnosed
- type diabetes
- ejection fraction
- chronic kidney disease
- cardiovascular disease
- single molecule
- high throughput
- peritoneal dialysis
- high resolution
- label free
- metabolic syndrome
- machine learning
- low cost
- adipose tissue
- patient reported outcomes
- mass spectrometry
- weight loss
- insulin resistance
- tandem mass spectrometry