Preclinical Assessment of the Analgesic Pharmacology of NKTR-181 in Rodents.

Caroline M KopruszinskiJuliana SwioklaYeon Sun LeeEdita NavratilovaLaurie VanderVeenMiao YangYi LiuTakahiro MiyazakiWilliam K SchmidtJonathan ZalevskyFrank Porreca

Published in: Cellular and molecular neurobiology (2020)

NKTR-181 had a slower onset, but similar efficacy, to morphine in the models studied supporting reduced abuse potential while maintaining analgesic effect in comparison with current opioids.

Keyphrases

neuropathic pain
anti inflammatory
chronic pain
pain management
spinal cord
spinal cord injury
human health
stem cells