An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome.
Manon SuerinkMar Rodríguez-GirondoHeleen M van der KliftChrystelle ColasLaurence BrugieresNoémie LavoineMarjolijn JongmansGabriel Capellá MunarD Gareth EvansMichael P FarrellMaurizio GenuardiYael GoldbergEncarna Gomez-GarciaKarl HeinimannJessica I HoellStefan AretzKory W JaspersonInbal KedarMitul B ModiSergey NikolaevTheo A M van OsTim RippergerDaniel RuedaLeigha SenterWenche SjursenLone SundeChristina TherkildsenMaria G TibilettiAlison H TrainerYvonne J VosAnja WagnerIngrid M WinshipKatharina WimmerStefanie Y ZimmermannHans F VasenChristi J van AsperenJeanine J Houwing-DuistermaatSanne W Ten BroekeMaartje NielsenPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
Our findings are consistent with previous reports that used more complex statistical methods to correct for ascertainment bias. These results underline the need for MMR gene-specific surveillance protocols for Lynch syndrome.
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