Multicenter study to compare the diagnostic performance of CLIA vs. FEIA transglutaminase IgA assays for the diagnosis of celiac disease.

Daan A R CastelijnA H Leontine MulderPieter van der PolJolien C HollanderTietie KuiperCaroline BijnensJan G M C DamoiseauxHetty J Bontkes

Published in: Clinical chemistry and laboratory medicine (2023)

All platforms have high diagnostic accuracy. The CLIA assays are more sensitive compared to the FEIA assay. A lower cut-off for the FEIA improves diagnostic performance, particularly in adult cases that, as demonstrated in this study, present with lower tTG-IgA levels compared to pediatric cases.

Keyphrases

celiac disease
high throughput
single cell