Sepsis-Related Outcomes of Patients with Philadelphia-Negative Myeloproliferative Neoplasms.
Luis F Gonzalez-MosqueraBernard MoscosoPool TobarDiana Cardenas-MaldonadoAlida I PodrumarRuben A MesaJohn A CuencaPublished in: Cancer investigation (2023)
We analyzed the National Inpatient Sample (NIS) database to study the sepsis-related outcomes in patients with Philadelphia negative myeloproliferative neoplasms (MPN). A total of 82,087 patients were included, most had essential thrombocytosis (83.7%), followed by polycythemia vera (13.7%), and primary myelofibrosis (2.6%). Sepsis was diagnosed in 15,789 (19.2%) patients and their mortality rate was higher than nonseptic patients (7.5% vs 1.8%; p < .001). Sepsis was the most significant risk factor of mortality (aOR, 3.84; 95% CI, 3.51-4.21), others included liver disease (aOR, 2.42; 95% CI, 2.11-2.78), pulmonary embolism (aOR, 2.26; 95% CI, 1.83-2.80), cerebrovascular disease (aOR, 2.05; 95% CI, 1.81-2.33), and myocardial infarction (aOR, 1.73; 95% CI, 1.52-1.96).
Keyphrases
- pulmonary embolism
- end stage renal disease
- newly diagnosed
- ejection fraction
- acute kidney injury
- intensive care unit
- acute lymphoblastic leukemia
- risk factors
- heart failure
- prognostic factors
- septic shock
- emergency department
- cardiovascular disease
- cardiovascular events
- skeletal muscle
- patient reported outcomes
- patient reported
- acute care