Impact of rare structural variant events in newly diagnosed multiple myeloma.
Monika ChojnackaBenjamin DiamondBachisio ZicchedduEven RustadKylee MaclachlanMarios PapadimitriouEileen Mary BoylePatrick BlaneySaad UsmaniGareth MorganCarl Ola LandgrenFrancesco MauraPublished in: bioRxiv : the preprint server for biology (2023)
Characterization of multiple myeloma genome revealed that more than half structural variants are not involved in recurrent events. Here, we demonstrate that these rare SVs hold potential for myeloma pathogenesis through their gene expression impact. Rare SVs contribute to MM heterogeneity and have implications for development of individualized treatment.