AI-powered transmitted light microscopy for functional analysis of live cells.
Dongyoung KimYoohong MinJung Min OhYoon-Kyoung ChoPublished in: Scientific reports (2019)
Transmitted light microscopy can readily visualize the morphology of living cells. Here, we introduce artificial-intelligence-powered transmitted light microscopy (AIM) for subcellular structure identification and labeling-free functional analysis of live cells. AIM provides accurate images of subcellular organelles; allows identification of cellular and functional characteristics (cell type, viability, and maturation stage); and facilitates live cell tracking and multimodality analysis of immune cells in their native form without labeling.
Keyphrases
- artificial intelligence
- single molecule
- living cells
- induced apoptosis
- high resolution
- deep learning
- optical coherence tomography
- cell cycle arrest
- machine learning
- high throughput
- big data
- high speed
- fluorescent probe
- label free
- signaling pathway
- convolutional neural network
- mass spectrometry
- cell death
- cell proliferation
- bioinformatics analysis
- single cell