Monitoring of sedation depth in intensive care unit by therapeutic drug monitoring? A prospective observation study of medical intensive care patients.
Richard J NiesCarsten MüllerRoman PfisterPhilipp S BinderNicole NosseirFelix S NettersheimKathrin KuhrMartin H J WiesenMatthias KochanekGuido MichelsPublished in: Journal of intensive care (2018)
Correlations between drug serum concentrations and clinical or neurophysiological monitoring procedures were weak. This might be due to intersubject variability, polypharmacy with drug-drug interactions, and complex metabolism, which can be altered in critically ill patients. Therapeutic drug monitoring is not beneficial to determine depth of sedation in ICU patients.