Randomized study of individualized pharmacokinetically-guided dosing of paclitaxel compared with body-surface area dosing in Chinese patients with advanced non-small cell lung cancer.
Jie ZhangFei ZhouHuiwei QiHuijuan NiQiong HuCaicun ZhouYunying LiIrina BaburinaJodi CourtneySalvatore J SalamonePublished in: British journal of clinical pharmacology (2019)
PK-guided PTX dosing significantly reduced grade 4 haematological toxicities and grade ≥ 2 neuropathy without an adverse impact on clinical outcomes.