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Orexin 2 receptor antagonism sex-dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice.

Ryan J KeenanHeather DaykinJeremy MethaLinda Cornthwaite-DuncanDavid K WrightKyra ClarkeSara OberrauchMaddison BrianSarah StephensonCameron J NowellGiancarlo AlloccaKevin J BarnhamDaniel HoyerLaura H Jacobson
Published in: British journal of pharmacology (2023)
receptor signalling/function, which may have implications for choice of hypnotic therapeutics in tauopathies.
Keyphrases
  • small molecule
  • physical activity
  • sleep quality
  • cerebrospinal fluid