Single-cell transcriptome analysis identifies skin-specific T-cell responses in systemic sclerosis.
Alyxzandria M GaydosikTracy TabibRobyn T DomsicZsuzsanna H McMahanRobert LafyatisPatrizia FuschiottiPublished in: Annals of the rheumatic diseases (2021)
Current available therapies to reverse or even slow progression of SSc lead to broad killing of immune cells and consequent toxicities, including death. Identifying the precise immune mechanism(s) driving SSc pathogenesis could lead to innovative therapies that selectively target the aberrant immune response, resulting in better efficacy and less toxicity.