Interaction of FGF9 with FGFR3-IIIb/IIIc, a putative driver of growth and aggressive behaviour of hepatocellular carcinoma.

Jakob PaurMaximilian VallerRebecca SienelKarin TaxauerKlaus HolzmannBrigitte MarianAndreas UnterbergerThomas Mohr Walter BergerAndja GvozdenovichJohannes SchimmingMichael Grusch Bettina Grasl-Kraupp

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

FGF9 acts via FGFR3-IIIb/IIIc to enhance growth and aggressiveness of HCC cells. Accordingly, blockade of the FGF9-FGFR3-IIIb/IIIc axis may be an efficient therapeutic option for HCC patients.

Keyphrases

end stage renal disease
ejection fraction
induced apoptosis
newly diagnosed
peritoneal dialysis
cell cycle arrest
prognostic factors
oxidative stress
pi k akt