Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis.
Akio UmemotoTakeshi KuwadaKoichi MurataMasahiro ShiokawaSakiko OtaYoshiki MurotaniAkihiro ItamotoKohei NishitaniHiroyuki YoshitomiTakayuki FujiiAkira OnishiHideo OnizawaKosaku MurakamiMasao TanakaHiromu ItoHiroshi SenoAkio MorinobuShuichi MatsudaPublished in: Arthritis research & therapy (2023)
Anti-cit-OPN antibodies were detected in patients with RA. IgG from patients with anti-cit-OPN antibodies aggravated RA, and anti-cit-OPN antibody was a marker of reduced the survival rate of TNF inhibitors in RA patients.