Keratinocyte IL-36 Receptor/MyD88 Signaling Mediates Malassezia-Induced IL-17-Dependent Skin Inflammation.

Hideaki MiyachiSeiichiro WakabayashiTakashi SugihiraReika AoyamaShinobu SaijoHanako Koguchi-YoshiokaManabu FujimotoGabriel NúñezHiroyuki MatsueYuumi Nakamura

Published in: The Journal of infectious diseases (2022)

Using a new skin infection model, it is shown that Malassezia-induced IL-17- dependent skin inflammation and control of fungal infection are mediated via keratinocyte IL-36 receptor/MyD88 signaling.

Keyphrases

oxidative stress
high glucose
soft tissue
wound healing
toll like receptor
endothelial cells
immune response
binding protein