Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study.

Tarun SinghalKelsey O'ConnorShipra DubeyHong PanRenxin ChuShelley HurwitzSteven CiceroShahamat TauhidDavid SilbersweigEmily SternMarie KijewskiMarcelo DiCarliHoward L WeinerRohit Bakshi

Published in: Neurology(R) neuroimmunology & neuroinflammation (2019)

This study suggests that [F-18]PBR06-PET detects widespread abnormal microglial activation in the cerebral gray matter in MS. Increased translocator protein binding in subcortical gray matter regions is associated with brain atrophy and may link to progressive MS.

Keyphrases

multiple sclerosis
mass spectrometry
white matter
ms ms
inflammatory response
subarachnoid hemorrhage
neuropathic pain
rheumatoid arthritis
systemic lupus erythematosus
small molecule
transcription factor
cerebral ischemia
spinal cord
blood brain barrier