FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms.

Richard M Monaghan Richard W NaylorDaisy FlatmanPaul R Kasher Simon G Williams Bernard D Keavney

Published in: Cardiovascular research (2024)

Taken together, we identify a pathogenic mechanism for FLT4 variants predisposing to TOF that is distinct from the known dominant negative mechanism of Milroy-causative variants. FLT4 variants give rise to conditions of the two circulatory subdivisions of the vascular system via distinct developmental pleiotropic molecular mechanisms.

Keyphrases

acute myeloid leukemia
copy number
tyrosine kinase
mass spectrometry
ms ms
squamous cell carcinoma
extracorporeal membrane oxygenation
dna methylation
lymph node metastasis
genome wide