Asthmatic bronchial epithelial cells promote the establishment of a Hyaluronan-enriched, leukocyte-adhesive extracellular matrix by lung fibroblasts.

Jourdan E BruneInkyung KangChristina K ChanKaitlyn A BarrowTessa K KolstadMaria P WhiteSteven F ZieglerThomas N WightJason S Debley

Published in: Respiratory research (2018)

Our findings demonstrate that BEC regulation of HA production by HLFs is altered in asthma, which may in turn promote the establishment of a more leukocyte-permissive ECM promoting airway inflammation in this disease.

Keyphrases

extracellular matrix
lung function
chronic obstructive pulmonary disease
peripheral blood
fluorescent probe
living cells
cystic fibrosis
air pollution
allergic rhinitis