NUDT15 intermediate metabolisers are associated with lower loss of response in paediatric Crohn's disease patients treated by combination treatment with infliximab and azathioprine.

Eun Sil KimSujin ChoiSo Yoon ChoiJi Hyung ParkByung-Ho ChoeSoo-Youn LeeMi Jin KimYon Ho ChoeBen Kang

Published in: Alimentary pharmacology & therapeutics (2022)

NUDT15 intermediate metabolisers were associated with lower LOR in paediatric patients with CD treated with IFX and AZA combination therapy. This finding may partially explain the longer durability of IFX in Korean children than their counterparts in Western countries.

Keyphrases

combination therapy
intensive care unit
emergency department
young adults
south africa
replacement therapy
smoking cessation