Sodium Multivitamin Transporter-Targeted Fluorochrome Facilitates Enhanced Metabolic Evaluation of Tumors Through Coenzyme-R Dependent Intracellular Signaling Pathways.
Feredun S AzariGregory T KennedyAshley ChangBilal NadeemPatrick Bou-SamraAustin ChangAlix SegilElizabeth BernsteinNeil T SullivanEvgeniy EruslanovJames DelikatnySunil SinghalPublished in: Molecular imaging and biology (2022)
These findings suggest that a SMVT-targeted NIR contrast agent can be a suitable tracer for imaging a wide range of malignancies as well as evaluating metabolic response to systemic therapies, similar to PET imaging with immune checkpoint inhibitors.
Keyphrases
- pet imaging
- cancer therapy
- positron emission tomography
- signaling pathway
- high resolution
- magnetic resonance
- photodynamic therapy
- fluorescence imaging
- computed tomography
- epithelial mesenchymal transition
- pi k akt
- drug delivery
- drug release
- fluorescent probe
- cell proliferation
- endoplasmic reticulum stress
- mass spectrometry
- drug induced
- pet ct