An Fgr kinase inhibitor attenuates sepsis-associated encephalopathy by ameliorating mitochondrial dysfunction, oxidative stress, and neuroinflammation via the SIRT1/PGC-1α signaling pathway.
Yuqiang LiuHan YangNanbo LuoYifei FuFang QiuZhenglong PanXiongjuan LiWenling JianXinping YangQingsheng XueYan LuoBuwei YuZhiheng LiuPublished in: Journal of translational medicine (2023)
To our knowledge, this is the first report of Fgr kinase inhibition markedly ameliorating SAE through activation of the SIRT1/PGC-1α pathway, and this may be a promising therapeutic target for SAE.
Keyphrases
- oxidative stress
- skeletal muscle
- signaling pathway
- ischemia reperfusion injury
- induced apoptosis
- healthcare
- diabetic rats
- acute kidney injury
- pi k akt
- intensive care unit
- dna damage
- early onset
- traumatic brain injury
- lipopolysaccharide induced
- septic shock
- epithelial mesenchymal transition
- lps induced
- cognitive impairment
- tyrosine kinase
- protein kinase
- inflammatory response
- endoplasmic reticulum stress
- brain injury