Identification of clonal skin myeloid cells by next-generation sequencing in myelodysplasia cutis.
Jeremie DelaleuM BattistellaK RathanaM-D Vignon-PennamenC LaurentC Ram-WolffP FenauxMarie JachietE ZuelgarayM BagotJ-D BouazizA de MassonPublished in: The British journal of dermatology (2020)
Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders characterized by dysplastic and ineffective blood cell production leading to blood cytopenias, and a risk of transformation to acute myeloid leukemia (AML). Skin lesions in patients with MDS include Sweet syndrome (SS), leucocytoclastic vasculitis, leukemia cutis and histiocytoid SS (H-SS), among others,.1,2 H-SS is a histological variant of SS differing from classical neutrophilic SS by a dermal infiltrate mostly made of immature cells of the myeloid lineage, that has been associated with myeloid malignancies.
Keyphrases
- acute myeloid leukemia
- induced apoptosis
- bone marrow
- allogeneic hematopoietic stem cell transplantation
- cell cycle arrest
- dendritic cells
- hematopoietic stem cell
- single cell
- wound healing
- soft tissue
- endoplasmic reticulum stress
- immune response
- oxidative stress
- signaling pathway
- cell death
- acute lymphoblastic leukemia
- mesenchymal stem cells
- pi k akt