Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 μg mg -1 ). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong near-infrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
Keyphrases
- drug release
- sensitive detection
- drug delivery
- reduced graphene oxide
- high resolution
- computed tomography
- fluorescence imaging
- photodynamic therapy
- quantum dots
- magnetic resonance imaging
- cancer therapy
- gold nanoparticles
- magnetic resonance
- stem cells
- radiation therapy
- mesenchymal stem cells
- image quality
- locally advanced
- smoking cessation
- drug induced
- silver nanoparticles