Increased nuchal translucency with normal karyotype and genomic microarray analysis: a multicenter observational study.

Elisa SpataroAdalgisa CordiscoCarlo LuchiGilda Rosaria FilardiGiulia MasiniLucia Pasquini

Published in: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (2022)

In fetuses with NT ≥3.5mm, both normal karyotype and array-CGH, the rate of morbidity-related outcome depends on NT size. A normal RASopathy testing and mid-trimester ultrasound are reassuring but the residual risk of morbidity-related outcome is increased compared to the general population, particularly if NT is > 6mm.

Keyphrases

magnetic resonance imaging
gestational age
high resolution
preterm birth
computed tomography
gene expression
copy number
mass spectrometry
pregnant women
double blind