Resorcinosides A and B, Glycosylated Alkylresorcinols from a Marine-Derived Strain of the Fungus Penicillium janthinellum.
Byeoung-Kyu ChoiThi Hoai Trinh PhanSunghoon HwangDong-Chan OhJong Soon KangHwa-Sun LeeThi Duy Ngoc NgoThi Thanh Van TranHee Jae ShinPublished in: Journal of natural products (2019)
Two new glycosylated alkylresorcinols, resorcinosides A (1) and B (2), were isolated from a strain of the fungus Penicillium janthinellum derived from a marine sediment sample collected from Cu Lao Cham Island, Vietnam. The structures of 1 and 2 were established by interpretation of 1D and 2D NMR and high-resolution ESIMS data, and their absolute configurations were confirmed by the coupling constant of the anomeric proton, acid hydrolysis, subsequent HPLC analysis, Mosher's method, and quantum-mechanics-based computational analysis of NMR chemical shifts. The structure elucidation indicated that 1 and 2 are new alkylresorcinols with d-glucose, and 2 has an α-pyrone moiety attached to the aromatic ring. Compound 1 exhibited cytotoxic activity against the NUGC-3 cancer cell line with a GI50 value of 9.3 μM.
Keyphrases
- high resolution
- mass spectrometry
- tandem mass spectrometry
- papillary thyroid
- magnetic resonance
- ms ms
- heavy metals
- solid state
- simultaneous determination
- molecular dynamics
- high performance liquid chromatography
- electronic health record
- squamous cell
- high speed
- big data
- room temperature
- blood glucose
- amino acid
- type diabetes
- data analysis
- adipose tissue
- childhood cancer
- quantum dots
- blood pressure
- ionic liquid