Estimation of Clearance and Bioavailability of Therapeutic Monoclonal Antibodies from Only Subcutaneous Injection Data in Humans Based on Comprehensive Analysis of Clinical Data.

Kenta HarayaTatsuhiko Tachibana

Published in: Clinical pharmacokinetics (2021)

This approach does not require intravenous injection data to separately estimate CL and F after subcutaneous injection in humans and can therefore accelerate the clinical development of mAbs.

Keyphrases

electronic health record
big data
ultrasound guided
machine learning
low dose