Identification of microbial antigens in liver tissues involved in the pathogenesis of primary biliary cholangitis using 16S rRNA metagenome analysis.

Tomohiro Katsumi Hidenori Sato Ryoko MurakamiTakumi HanataniFumi UchiyamaFumiya SuzukiKeita MakiKyoko HoshikawaHiroaki HagaTakafumi SaitoYoshiyuki Ueno

Published in: PloS one (2024)

S. panacis antigen was specifically detected in the portal areas of PBC liver tissues. The introduction of foreign-derived antigens into the liver as an environmental factor could be a possible mechanism for the development of PBC.

Keyphrases

gene expression
dendritic cells
risk assessment