A new cycloheptane derivative from the fungus Penicillium crustosum JT-8.

Jun-Tao HuJia-Peng WangYan ShuXue-Yun CaiCheng-Tong SunHao DingLe Cai Zhong-Tao Ding

Published in: Natural product research (2021)

A new highly oxygenated cycloheptane derivative crustane (1), along with fourteen known compounds (2-15) were isolated from Penicillium crustosum JT-8. The structure of compound 1 was determined by extensive spectroscopic data, DP4+ probability analyses and dimolybdenum CD method. Compound 1 exhibited moderate antibacterial activity against Staphylococcus aureus with MIC of 4.0 μg/mL.

Keyphrases

staphylococcus aureus
molecular docking
electronic health record
water soluble
high intensity
big data
nk cells
escherichia coli
data analysis
deep learning
pseudomonas aeruginosa