Human β-defensin-2 suppresses key features of asthma in murine models of allergic airways disease.
James W PinkertonRichard Y KimLouis KoeningerNicole S ArmbrusterNicole G HansbroAlexandra C BrownRanjith JayaramanSijie ShenNisar MalekMatthew A CooperPeter NordkildJay C HorvatBenjamin Anderschou Holbech JensenJan WehkampPhilip Michael HansbroPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2020)
These data indicate that hBD2 reduces the hallmark features and has potential as a new therapeutic agent in allergic and especially steroid-resistant asthma.