GLUT-1/PKM2 loop dysregulation in patients with non-ST-segment elevation myocardial infarction promotes metainflammation.

Francesco Canonico Daniela PedicinoAnna SeverinoRamona VinciDavide FlegoEugenia PisanoAlessia d'AielloPellegrino CiampiMyriana Ponzo Alice BonanniAstrid De CiutiisSara RussoMarianna Di SarioGiulia AngeliniPiotr SzczepaniakAlfonso BaldiBoguslaw KapelakKarol WierzbickiRocco Antonio Montone Domenico D'AmarioMassimo MassettiTomasz J Guzik Filippo Crea Giovanna Liuzzo

Published in: Cardiovascular research (2022)

NSTEMI patients exhibit dysregulation of the GLUT-1/PKM2 metabolic loop characterized by nuclear translocation of PKM2, where it acts as a transcription regulator of pro-inflammatory genes. This detrimental loop might represent a new therapeutic target for personalized medicine.

Keyphrases

st segment elevation myocardial infarction
transcription factor
percutaneous coronary intervention
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
genome wide
gene expression
atrial fibrillation