BCL6 BTB-specific inhibition via FX1 treatment reduces Tfh cells and reverses lymphoid follicle hyperplasia in Indian rhesus macaque (Macaca mulatta).

Yanhui CaiMeagan A WatkinsFengtian XueYong AiHuiming ChengCecily C MidkiffXiaolei WangXavier AlvarezAdi Narayana Reddy PoliJoseph M SalvinoRonald S VeazeyLuis J Montaner

Published in: Journal of medical primatology (2019)

B-cell lymphoma 6 inhibition may represent a novel strategy to reduce hyperplastic lymphoid B-cell follicles and decrease Tfh cells.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
combination therapy