Low omega-3 polyunsaturated fatty acids predict reduced response to standard antidepressants in patients with major depressive disorder.

Sofia CussottoInês DelgadoGiovanni OrioloJonas KemperDiane BegarieSandra DexpertJulie SauvantMarion LeboyerBruno AouizerateRocío Martin-SantosMartin SchaeferLucile Capuron

Published in: Depression and anxiety (2022)

These results show that baseline levels of PUFAs predict later response to standard antidepressants in depressed subjects. They suggest that PUFA intake and/or metabolism represent a novel modifiable tool for the management of unresponsive depressed patients.

Keyphrases

major depressive disorder
bipolar disorder
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
patient reported outcomes
physical activity