Glomerular Elasticity and Gene Expression Patterns Define Two Phases of Alport Nephropathy.

Joonho YoonZhenan LiuMathew AlabaLeslie A BruggemanPaul JanmeyCarlos AranaOluwatoyosi AyenuyoIsabela MedeirosViji NairSean EddyMatthias KretzlerJoel M HendersonAbijit NaikAudrey N ChangR Tyler Miller

Published in: bioRxiv : the preprint server for biology (2024)

Col4α3-/- nephropathy progresses in two phases. The first is characterized by podocytopathy, increased glomerular capillary deformability and accelerated podocyte loss, and the second by increased capillary wall stiffening and renal inflammatory and profibrotic pathway activation. The response of podocytes to TUDCA treatment provides insights into signaling pathways in Alport and related nephropathies.

Keyphrases

diabetic nephropathy
high glucose
gene expression
endothelial cells
signaling pathway
dna methylation
oxidative stress
epithelial mesenchymal transition
combination therapy
induced apoptosis
endoplasmic reticulum stress