Biomineralized nanoparticles enable an enzyme-assisted DNA signal amplification in living cells.

Mengyi XiongMeng ZhangQin LiuChan YangQingji XieGuoliang KeHong-Min MengXiao-Bing Zhang Weihong Tan

Published in: Chemical communications (Cambridge, England) (2020)

The enzymatic-assisted signal amplification of DNA sensors is rarely applied in living cells due to the difficulties in protein delivery. In this study, we have proposed a biomineralization-based DNA nanoprobe to transport nucleases and DNA sensors for enzyme-assisted imaging of microRNA in living cells.

Keyphrases

living cells
single molecule
fluorescent probe
circulating tumor
nucleic acid
cell free
high resolution
hydrogen peroxide
low cost
photodynamic therapy
amino acid