Drug-Induced Liver Injury: An Institutional Case Series and Review of Literature.
Vijay GayamMazin KhalidBinav ShresthaMuhammad Rajib HossainSumit DahalPavani GarlapatiArshpal GillAmrendra Kumar MandalRuby SanghaPublished in: Journal of investigative medicine high impact case reports (2018)
Drug-induced liver injury (DILI) is the most common cause of acute liver failure in the USA. DILI can be broadly classified as Intrinsic and Idiosyncratic. Identifying predictors and at-risk patients are challenging but can have a substantial clinical implication. This case report series demonstrates the importance of valproic acid, fluconazole, and amiodarone as potential hepatoxic agents of drug-induced liver injury leading to acute hepatic failure. The causality in all cases was established by Roussel Uclaf Causality Assessment Method/Council for International Organizations of Medical Sciences score and Naranjo Algorithm. Obesity, hypo-perfusion state, and concurrent hepatotoxic agent might identify at-risk patients. Further studies are required to understand the risk factors.
Keyphrases
- liver failure
- drug induced
- end stage renal disease
- ejection fraction
- risk factors
- newly diagnosed
- case report
- hepatitis b virus
- adverse drug
- prognostic factors
- healthcare
- type diabetes
- metabolic syndrome
- peritoneal dialysis
- insulin resistance
- machine learning
- respiratory failure
- patient reported outcomes
- magnetic resonance imaging
- intensive care unit
- body mass index
- weight loss
- deep learning
- radiation therapy
- rectal cancer
- weight gain
- acute respiratory distress syndrome
- aortic dissection
- locally advanced