Applying Next-Generation Sequencing to Track HIV-1 Drug Resistance Mutations Circulating in Portugal.
Victor PimentelMarta PingarilhoCruz S SebastiãoMafalda MirandaFátima GonçalvesJoaquim CabanasInês CostaIsabel DiogoSandra FernandesOlga CostaRita Corte-RealMaria do Rosario Oliveira MartinsSofia G SeabraAna Barroso AbecasisPerpétua GomesPublished in: Viruses (2024)
We present the first evidence on TDR and ADR to INSTI regimens in followed up patients presenting for healthcare in Portugal. We observed low levels of TDR to INSTIs among ART-naïve and moderate levels in ART-exposed patients. Regimens containing PIs could be an alternative second line in patients with intermediate or high-level drug resistance, especially against second-generation INSTIs (dolutegravir, bictegravir, and cabotegravir).
Keyphrases
- end stage renal disease
- healthcare
- antiretroviral therapy
- chronic kidney disease
- ejection fraction
- hiv infected
- prognostic factors
- hepatitis c virus
- peritoneal dialysis
- hiv positive
- human immunodeficiency virus
- emergency department
- gene expression
- dna methylation
- patient reported outcomes
- copy number
- high intensity
- case report
- men who have sex with men
- electronic health record