Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses.
Maike SperkRobert van DomselaarJimmy Esneider RodriguezFlora MikaeloffBeatriz Sá VinhasElisa SacconAnders SönnerborgKamal SinghSoham GuptaÁkos VégváriUjjwal NeogiPublished in: Journal of proteome research (2020)
Emerging and re-emerging infectious diseases due to RNA viruses cause major negative consequences for the quality of life, public health, and overall economic development. Most of the RNA viruses causing illnesses in humans are of zoonotic origin. Zoonotic viruses can directly be transferred from animals to humans through adaptation, followed by human-to-human transmission, such as in human immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and, more recently, SARS coronavirus 2 (SARS-CoV-2), or they can be transferred through insects or vectors, as in the case of Crimean-Congo hemorrhagic fever virus (CCHFV), Zika virus (ZIKV), and dengue virus (DENV). At the present, there are no vaccines or antiviral compounds against most of these viruses. Because proteins possess a vast array of functions in all known biological systems, proteomics-based strategies can provide important insights into the investigation of disease pathogenesis and the identification of promising antiviral drug targets during an epidemic or pandemic. Mass spectrometry technology has provided the capacity required for the precise identification and the sensitive and high-throughput analysis of proteins on a large scale and has contributed greatly to unravelling key protein-protein interactions, discovering signaling networks, and understanding disease mechanisms. In this Review, we present an account of quantitative proteomics and its application in some prominent recent examples of emerging and re-emerging RNA virus diseases like HIV-1, CCHFV, ZIKV, and DENV, with more detail with respect to coronaviruses (MERS-CoV and SARS-CoV) as well as the recent SARS-CoV-2 pandemic.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- zika virus
- dengue virus
- human immunodeficiency virus
- mass spectrometry
- infectious diseases
- antiretroviral therapy
- hepatitis c virus
- high throughput
- aedes aegypti
- public health
- hiv infected
- endothelial cells
- hiv positive
- hiv aids
- high resolution
- induced pluripotent stem cells
- hiv testing
- men who have sex with men
- gas chromatography
- electronic health record
- capillary electrophoresis